Oncology Therapeutics Targeting the Metabolism of Amino Acids
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چکیده
منابع مشابه
The Metabolism of Amino Acids
It was shown by Seth and Luck (1) that the intestinal absorption of glycine and alanine by rabbits was followed by pronounced aminoacidemia. Other amino acids when administered in similar amounts provoked smaller increases in the amino nitrogen content of the blood. Glutamic acid and aspartic acid were absorbed with but a slight aminoacidemia. The question then arose as to whether these strikin...
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For an adult in N balance, apart from small amounts of amino acids required for the synthesis of neurotransmitters, hormones, etc, an amount of amino acids almost equal to that absorbed from the diet can be considered to be "surplus" in that it will be catabolized. The higher diet-induced thermogenesis from protein than from carbohydrate or fat has generally been assumed to be due to increased ...
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Studies previously reported (l-3)) involving the constant intravenous infusion of a number of amino acids, singly and in combination, have permitted the authors to obtain data concerning a number of physiological and biochemical phenomena associated with amino acid metabolism. The present report deals with the effect of amino acid infusion upon the renal excretion of ammonia. In this phase of m...
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Lactate, once considered a waste product of glycolysis, has emerged as a critical regulator of cancer development, maintenance, and metastasis. Indeed, tumor lactate levels correlate with increased metastasis, tumor recurrence, and poor outcome. Lactate mediates cancer cell intrinsic effects on metabolism and has additional non-tumor cell autonomous effects that drive tumorigenesis. Tumor cells...
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In the United States, guinea fowl (GF) production has continued to increase due to increased demand and consumption of specialty meats . However, there is lack of information on optimum nutrients, such as amino acids, that would support optimum growth performance and minimize production cost of the GF . The amino acid methionine is most limiting in poultry feeding while methionine and cysteine ...
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ژورنال
عنوان ژورنال: Cells
سال: 2020
ISSN: 2073-4409
DOI: 10.3390/cells9081904